Small Intestinal Crypt of Lieberkühn.

You selected: Paneth cell

Differentiated crypt Paneth cell. Unlike other lineages, Paneth cells migrate to the crypt base. They have a long life-span of ~28 days. Paneth cells are noted for their prominent secretory appartus. Granules are readily visulaized using a variety of stains including the Phloxine-Tartrazine histochemical stain. The granules contain digestive enzymes (phospholipases, peptidases), mucins and anti-microbial factors such as lysozyme, the defensin-related cryptdins and IgA taken up from lamina propria plasma cells. As all products enter the crypt lumen, these cells provide a primary defense to microbial colonization in this sensitive regions of the small intestine. Only mammalian herbivores and omnivores have Paneth cells.

Key points in this image
Paneth cell | granule | lumen | undifferentiated crypt stem cell | lamina propria | nucleus |
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Information
Module Name: crypt
Module Title: Small Intestinal Crypt of Lieberkühn.
Image Info: Electron micrograph taken by Lisa Roberts, 10,000X (?) magnification.
Created by: Lynn Bry
Contact Email:bryl@medicine.wustl.edu
Last modified: Dec 12th, 1996.
Created with Annotation 1.0