MadSci Network: Genetics |
well, this is a hard question to answer but i will try. According to Watson et al in "Molecular Biology of the Gene", 4 Ed each chromosome in a mammalian cell is believed to be made up of a single very long DNA molecule which is about 5cm in length. This is effectively compacted into each chromosome. A study of the DNA lengths in each chromosome in several organisms using the Entrez database on the internet shows that the base pair lengths in each chromosome of several evolutionary distinct organisms can be quite different. Some of the data is shown in table 1: Table 1 Table 2 Organism Chromosome Chromosome length in Bp Organism Length of mitochondrial DNA Homo Sapiens 20 90 000 K Homo sapiens 16 K Homo Sapiens 19 100 000 K great Indian Rhino 16829 Homo Sapiens 17 125 000 K donkey 16670 Homo Sapiens 6 225 000 K atlantic cod 16696 Dros. Melanogaster 4 1750 K locust(L.migratoria) 15722 Dros. Melanogaster 3 50 000 K Dros. Melanogaster 2 51 000 K Mouse (Mus musculus)11 45000 K If we consider the mitochondrial DNA we see much greater homogeneity in DNA length (Table 2). This is most likely explained by the theory that mitochondria were once separate organisms that were incorporated into the cellular structure of eukaryotic cells. The slight differences in mitochondrial DNA length are due to heteroplasmy, that is differences in length of the control regions of the mitochondrial DNA. Overall it is possible to say that there only a very approximate increase in the degree of complexity of organisms (number of different proteins produced) with increasing size of genomes. Whilst this latter fact is indirectly related to your question, it is nevertheless an interesting fact. I hope this answer was to the point and not too brief. Robert DEYES BSc MSc