| MadSci Network: Immunology |
According to "The World of the Cell" (by Becker & Deamer, 2nd ed), endocytosis describes the general process of a cell internalizing material that is present outside of the cell (i.e. extra-cellular material) through the invagination of the plasma membrane. Endocytosis can refer to receptor-mediated endocytosis, pinocytosis or phagocytosis. Of these three processes, phagocytosis is generally used to describe the cellular "ingestion" of large particulate matter (e.g. bacteria or viruses). Indeed phagocytosis is often equated with "cell eating". Receptor-mediated endocytosis and pinocytosis typically involve the uptake of smaller materials. Perhaps more pertinent to your interests, phagocytosis is a term commonly used by immunologists to describe macrophage ingestion of bacteria or viruses. Thus, in the context of immunology, phagocytosis is the specific and accepted terminology to describe "ingestion" of pathogens. While endocytosis might be technically correct, it is not commonly used to describe pathogen "ingestion". Hope that helps. ETC PS You can also check out some sites on phagocytosis and pathogens by searching the web. One example is at http://www.comet.chv.va.us/QUILL/mac.html-ssi
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