Re: What cells make interferon-gamma in response to superantigen injection?

T cells make the cytokine interferon gamma in response to superantigen.  
Superantigens have the ability to bind MHC molecules on the surface of 
cells called antigen presenting cells, and at the same time bind to a 
protein on T cells called the T Cell Receptor (TCR).  This cross linking 
between antigen presenting cell and T cell via MHC and TCR leads to 
stimulation of the T cell, which then releases interferon gamma.  Not all T 
cells have the same TCR, and specific superantigens only bind to specific 
families of TCRs...so a specific superantigen will activate a subset of T 
cells, and these particular ones will be the cells releasing the interferon 
gamma.