Subject: Using common proteine domains for a faster Human Genome Project?

Dear Sir or Madam

Thanks very much for your service. Here's my question:
Wouldn't it be a good idea to use the common protein domains for
getting
a coarse overview about the human (or other species') genome within a
short 
time?

There are about 150 proteine parts that occur again and again in the
proteines
of the living cell. Recognizing them in the amino acid sequence of a
newly
sequenced proteine (corresponding to a newly sequenced gene) helps
very much
in understanding the tertiary structure of the proteine and it's
function,
since common domains indicate a common origin of the gene (mostly by 
recombination of other genes or the process of gene doubling and
subsequent
specialization) and there are certain domains always responsible for
the same
purpose (for example the inner side of membrane proteines). Of course,
there 
are little mutations (point mutations) in the instances of a domain,
but 
knowledge about the occurences of all the domains within the human
genome 
would help in any case.

So one could use the domains (I mean the corresponding DNA) as DNA
probes 
(marked by radioactive isotopes or by fluorescence) in order to get
the 
overview over the relevant parts of the genome. One could also use
such 
domain-DNA probes for rapidly investigating the expression pattern of
the 
domains in specialized cells by using them on the cell's mRNA.

Thank you for your time.

Best regards
  Bruno                                               
mailto:daniel@fzi.de

Re: Using common proteine domains for a faster Human Genome Project?