MadSci Network: Anatomy
Query:

Re: WHY WOULD STARVATION RESULT IN KETONES IN THE URINE?

Date: Fri Sep 18 11:31:54 1998
Posted By: john young, Faculty, Anatomy, Howard University
Area of science: Anatomy
ID: 906115618.An
Message:

This question sounds a lot like a homework question.  Can you find the 
answer in your own text?  If not, here's what Guyton's Textbook of Medical 
Physiology will tell you:  starvation causes the body's fat cells to 
release lipids into the circulation.  They are degraded into small 
molecules of acetate in the liver; the liver forms acetoacetate from them 
and releases them into the bloodstream as nutrients for tissues.  Since 
acetoacetate is a keto acid, this condition results in "ketosis" high 
levels of ketones in the blood and urine.  A high sugar diet would not 
normally affect the urine unless you are diabetic, and cannot metabolize 
sugar.  In diabetes, glucose levels are elevated in the blood and urine; 
also, since glucose cannot be used as a nutrient by muscles, fat is 
converted to acetoacetate once again, leading to ketone bodies in the 
urine.


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