Re: Does alcohol or narcotic consumption have any effect on anesthetics.

Chronic(long-term) substance abuse tends to increase one's tolerance to 
anesthetics through a metabolic process called enzyme induction chiefly in 
the liver cells. As a result the dosage of anesthetics either IV or 
inhalational is increased. Acute intoxication tends to decrease the dosage 
of anesthetics needed. Two extremely dangerous acute situations involve 
cocaine and heroin intoxications and general anesthesia in which death from 
cardiac arrest can occur. One week after occasional drug use will have 
little or no effect on the conduct of general anesthesia.