Subject: Glycolysis: How does NAD*H 'know' oxygen is present in the mitochondria

In glycolysis, NAD*H enters the mitochondria to produce ATP in the 
presence of oxygen.  In the absence of Oxygen, NAD*H is shuttled to 
pyruvate.  According to "Metabolism at a Glance,"  once inside the 
mitochondrial membrane NAD*H is converted using maltase and other 
cofactors.  Many of these cofactors are oxadized.  Is it possible that 
production of the shuttle responsible for taking NAD*H to the 
mitochondria is triggered by the presence of oxygen?  Perhaps 
chemosynthesis is the key and NAD*H is attracted by the concentration 
gradient? How does NAD*H "know" whether to contunue aerobically or 
anaerobically?  All resources have skirted around this question, 
perhaps you can find out if the answer is known.

Re: Glycolysis: How does NAD*H 'know' oxygen is present in the mitochondria