| MadSci Network: Genetics |
Your idea is a good one, but it is just out of reach of today's science. First of all, we do not know the function of every human gene quite yet. The Human Genome Project is an ongoing research project with participants at many institutions. Different labs are trying to determine the function of different genes in the human genetic makeup. They are making great progress, but are still several years from completion. Until the HGP is completed, we cannot determine every trait or genetic disease an embryo might develop. We do know the entire genetic makeup of many simpler organisms, such as viruses and bacteria, and that is why we are able to do gene manipulation experiments with them (as you plan to do). We have the techniques available today to be able to remove and replace genes, though in some cases it is an especially tricky procedure and can lead to complications (e.g. you can accidentally take out part of a neighboring gene with it, or your restriction enzyme (which cuts DNA at certain places) might cut genes other than the one you intended). Thus, our inability to engineer human eggs is caused by our lack of complete knowledge of the human genome and our inability to predict the unknown effects our engineering processes might have on the embryo. Oak Ridge National Laboratory has an excellent web page on the Human Genome Project. You can find it at: http://www.ornl.gov/TechResources/Human_Genome/home.html It has information on the HGP, as well as primers and FAQs about molecular genetics and applications of the HGP. Good luck on your experiment, and I hope you find the world of genetic engineering as fascinating as I do. Dave Eckert
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