MadSci Network: Genetics
Query:

Re: Is it possible? Has an experiment like/similar to this ever been done?

Date: Thu Jan 28 15:36:56 1999
Posted By: David Eckert, Undergraduate, Dept. of Microbiology, BS Molecular Biology, Brigham Young University
Area of science: Genetics
ID: 909156967.Ge
Message:

Your idea is a good one, but it is just out of reach of today's science.  
First of all, we do not know the function of every human gene quite yet.  
The Human Genome Project is an ongoing research project with participants 
at many institutions.  Different labs are trying to determine the function 
of different genes in the human genetic makeup.  They are making great 
progress, but are still several years from completion.  Until the HGP is 
completed, we cannot determine every trait or genetic disease an embryo 
might develop.  We do know the entire genetic makeup of many simpler 
organisms, such as viruses and bacteria, and that is why we are able to do 
gene manipulation experiments with them (as you plan to do).  We have the 
techniques available today to be able to remove and replace genes, though 
in some cases it is an especially tricky procedure and can lead to 
complications (e.g. you can accidentally take out part of a neighboring 
gene with it, or your restriction enzyme (which cuts DNA at certain places) 
might cut genes other than the one you intended).  Thus, our inability to 
engineer human eggs is caused by our lack of complete knowledge of the 
human genome and our inability to predict the unknown  effects our 
engineering processes might have on the embryo.

Oak Ridge National Laboratory has an excellent web page on the Human Genome 
Project.  You can find it at: 

http://www.ornl.gov/TechResources/Human_Genome/home.html

It has information on the HGP, as well as primers and FAQs about molecular 
genetics and applications of the HGP.  

Good luck on your experiment, and I hope you find the world of genetic 
engineering as fascinating as I do.

Dave Eckert


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