MadSci Network: Immunology

Subject: What's the difference of TH1 cells and TH2 cells effect?

Date: Fri May 7 12:57:07 1999
Posted by h5nl
Grade level: undergrad School: Mississippi State University
City: Mississippi State State/Province: MS Country: USA
Area of science: Immunology
ID: 926099827.Im

Both cells are derived from CD4+ helper T cells. T cells that differentiate into TH1 principally secrete interferon gamma, 
lymphotoxin and IL-2. These will eventually, mainly stimulate the action of macrophage cells. On the other hand, TH2 cells 
are developed from T cells and mainly secreted IL-4 and IL10. Thier ultimate effect basically are to stimulate production of IG 
E and eventually stimulate mast cell degranulation. What i am curious about is what is the general major distinction of their 
effect on infection. Like, is it TH 1 cells more specific for intercellular bacteria infected cells and TH 2 specific for extracellular 
bacteria infected cells.

Re: What's the difference of TH1 cells and TH2 cells effect?

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