MadSci Network: Medicine |
Great question! To my knowledge, while there are bateria (prokaryotes) which routinely exchange genetic material, there are no human cancers which do so. This type of exchange is performed to enhance genetic diversity of some bacteria and does not normally occur in higher eukaryotes. If you would like to learn more about exchange of genetic material in prokaryotes textbooks of microbiology are a good place to start. At the heart of your query is the nature of a cancer cell. What is a cancer cell? Cancer cells are cells found normally in one's body. A cancer arises when a cell is mutated in such a way that it can grow and divide abnormally. While it is true that many cell types in our bodies can grow and divide, cancer cells grow better than neighboring cells and their growth is unregulated. Because the cancer cell was part of our bodies before it became a cancer cell, it is very difficult for the immune system to fight it. Almost every cell in the body displays a molecule on its surface that notifies the immune system that it belongs in our body {it is "self"}. Cancer cells still possess this molecule. When a cell does not possess this molecule or it has been mutated, then the immune system is alerted that something that is "not self" or dangerous is present. The solution you have proposed to B's cancer has many problems. First, unless A and B are identical twins, B's normal cells (and, therefore, B's cancer too) will be recognized as "not self". This will produce a vigorous rejection of B's cells by A's immune system. Second, the transplant from B might contain immune cells from B, which would recognize any of A's cells as "not self". This could cause the reverse reaction called "graft-versus-host disease". {This is a particular problem in bone marrow transplants.} This a very painful and potentially fatal reaction. Cancer or tumor immunobiology is a burgeoning and very exciting field of immunology. The question you have posed calls upon many different aspects of immunology such as development of recognition of "self" versus "nonself", transplantation/graft rejection, and cancer immunotherapy. Many lines of research are now underway to learn how we can manipulate the immune system to selectively kill cancer cells. However, as I mentioned above, since cancer cells look like "self", this is quite difficult. If you would like to learn more about how this amazing system works in your body there are several introductory immunology textbooks available in university libraries or in some online bookstores.
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