| MadSci Network: Medicine |
Great question!
To my knowledge, while there are bateria (prokaryotes) which routinely
exchange genetic material, there are no human cancers which do so. This
type of exchange is performed to enhance genetic diversity of some bacteria
and does not normally occur in higher eukaryotes. If you would like to
learn more about exchange of genetic material in prokaryotes textbooks of
microbiology are a good place to start.
At the heart of your query is the nature of a cancer cell. What is a
cancer cell? Cancer cells are cells found normally in one's body. A cancer
arises when a cell is mutated in such a way that it can grow and divide
abnormally. While it is true that many cell types in our bodies can grow
and divide, cancer cells grow better than neighboring cells and their growth
is unregulated.
Because the cancer cell was part of our bodies before it became a
cancer cell, it is very difficult for the immune system to fight it. Almost
every cell in the body displays a molecule on its surface that notifies the
immune system that it belongs in our body {it is "self"}. Cancer cells
still possess this molecule. When a cell does not possess this molecule or
it has been mutated, then the immune system is alerted that something that
is "not self" or dangerous is present.
The solution you have proposed to B's cancer has many problems. First,
unless A and B are identical twins, B's normal cells (and, therefore, B's
cancer too) will be recognized as "not self". This will produce a vigorous
rejection of B's cells by A's immune system. Second, the transplant from B
might contain immune cells from B, which would recognize any of A's cells as
"not self". This could cause the reverse reaction called "graft-versus-host
disease". {This is a particular problem in bone marrow transplants.} This
a very painful and potentially fatal reaction.
Cancer or tumor immunobiology is a burgeoning and very exciting field
of immunology. The question you have posed calls upon many different
aspects of immunology such as development of recognition of "self" versus
"nonself", transplantation/graft rejection, and cancer immunotherapy. Many
lines of research are now underway to learn how we can manipulate the immune
system to selectively kill cancer cells. However, as I mentioned above,
since cancer cells look like "self", this is quite difficult.
If you would like to learn more about how this amazing system works in
your body there are several introductory immunology textbooks available in
university libraries or in some online bookstores.
Try the links in the MadSci Library for more information on Medicine.