MadSci Network: Medicine

Re: How much salicylic acid can we give a mice without hurting it?

Date: Fri Oct 22 15:58:37 1999
Posted By: Mike Crawford, MadSci Admin
Area of science: Medicine
ID: 940006561.Me

According to the Merck Index (an encyclopedia of drugs, chemicals, etc.) the 
dose of salicylic that kills 50% of mice (the lethal dose 50 or LD50) is 500 
milligrams/kilogram of mouse.  Salicylic acid is usually used topically 
(externally) as is not used internally, as it will cause vomiting, abdominal 
pain, etc.  You may not want to use this on mice, they are likely not to be 

In case you are talking about acetylsalicylic acid (aspirin), the LD50 in mice 
is 1-2 grams/kilogram.  Be careful with any drug you use on mice--they'll 
appreciate it.

Michael Crawford

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