MadSci Network: Cell Biology |
The cell membrane is not a homogenous mixture of molecules. It is composed of proteins, lipids, and carbohydrates. All of these molecules are affected by temperature changes. The membrane's Tm (melting point) is affected by the composition of the membrane. Membrane permeability is a function of this composition and of transporters present in the membrane. You may find the following review helpful: "Morphological, physiological and biochemical parameters associated with cell injury: a review." Immunopharmacol Immunotoxicol 1989;11(4):539-58. If you do not have access to this journal, your library can order a copy of the paper through the National Library of Medicine, Bethesda MD 20892. An exciting new field of biology is the study of specific groups of molecules present in the membrane. It has been discovered that certain components of the membrane aggregate (clump) together. These aggregates are called rafts and may be important in cell signalling. There is at least one excellent review of this area in the 1998 journal Annual Reviews of Cellular and Developmental Biology. Thus the membrane may not only govern cellular permeability, but may also play a role in cellular signalling.
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