MadSci Network: Medicine
Query:

Re: How does pure oxygen affect the heart and its conduction system?

Date: Fri Mar 24 01:18:57 2000
Posted By: Howard Stacey, Staff, Pharmacology, Webster-netwizzard
Area of science: Medicine
ID: 953846496.Me
Message:

Hi Pat, This is an interesting question. Here in the UK we talk about 
something called 'hypoxic drive' which relates to the fact that our 
respiratory system requires a certain level of C02 to act as a stimulus to 
breathe. The respiratory systems of patients suffering from chronic lung 
tissue diseases, asbestosis etc, use a higher level of hypoxic drive, 
which means that they exist happily on a much higher than normal level of 
carbon dioxide in the blood. If these patients were to be given 02 therapy 
at a doseage higher than 28% their breathing stimulus would be impaired. 
Thus I think the same would aply to a normal heart. Too much O2 must shut 
down the CO2 breating centres which would therefore stop the heart. For 
further reference check out an ambulance manual on oxygen therapy.



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