MadSci Network: Genetics |
That would be like "Jurassic Park" for humans... Your scenario is possible in theory, but the pitfalls would be many and they would be both technical and ethical... It is possible to extract DNA from well-preserved "ancient" bones, but it is highly unlikely that you would recover all of the DNA sequences that constitute the entire genetic make-up of your "supergiant" human ancestor. Just like the dinosaurs in Jurassic Park, there would be extensive "gaps" where you would not know what the original DNA sequences encoded. The more likely senario would be to try to isolate the genes that were of most interest from this humanoid ancestor; that is, the gene or genes that give rise to the supergiant appearance. This gene or genes could then be introduced into the a modern human. Here's another place where things get tricky. Technically, you would have to introduce this ancient DNA into a location or locations in the modern human genome where these sequences would be "expressed" (transcribed and translated into protein) and you would have to engineer these new genes such that expression occurred at the right time and in only the right cells during development of your "new and improved" human. At the moment, it is very difficult at best to "target" DNA sequences to specific locations in the human genome. It is also very difficult to ensure that your newly introduced genes are turned on and off at the right time in exactly the right place. Furthermore, you would be introducing this DNA from the "supergiant" into germ line cells (i.e., either sperm or egg, you would tend to use the egg since only one of many sperm actually fertilize any one egg) of a human; this would be required so that the new DNA sequences could be turned on during the appropriate time during the development of the supergiant fetus. This would bring numerous ethical considerations, such as, what do you do with all the malformed (developmentally incorrect) fetuses that would be expected from your experiments (very few things work on the first try in science). How would you incubate your new creations so that they could develop? Surrogate moms for supergiants??? What if you have introduced DNA sequences that give unexpected charateristics to your supergiant humans; will you engineer a "lethal mutation" into your new race that can be activated under special conditions. In general, the technical problems are many, but the more troubling issues are certainly the ethical questions that such a line of experimentation would raise. Hope this answers your question.
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