MadSci Network: Genetics
Query:

Re: Could DNA from ancient bones be combined with ours 2 create hybrid lifeform

Date: Fri Jul 21 16:57:11 2000
Posted By: Mark Woelfle, Faculty, Molecular Biology, Vanderbilt University
Area of science: Genetics
ID: 963372276.Ge
Message:

That would be like "Jurassic Park" for humans...

Your scenario is possible in theory, but the pitfalls would be many and 
they would be both technical and ethical...

It is possible to extract DNA from well-preserved "ancient" bones, but it 
is highly unlikely that you would recover all of the DNA sequences that 
constitute the entire genetic make-up of your "supergiant" human ancestor. 
Just like the dinosaurs in Jurassic Park, there would be extensive "gaps" 
where you would not know what the original DNA sequences encoded. The more 
likely senario would be to try to isolate the genes that were of most 
interest from this humanoid ancestor; that is, the gene or genes that give 
rise to the supergiant appearance. This gene or genes could then be 
introduced into the a modern human.

Here's another place where things get tricky. Technically, you would have 
to introduce this ancient DNA into a location or locations in the modern 
human genome where these sequences would be "expressed" (transcribed and 
translated into protein) and you would have to engineer these new genes 
such that expression occurred at the right time and in only the right cells 
during development of your "new and improved" human. At the moment, it is 
very difficult at best to "target" DNA sequences to specific locations in 
the human genome. It is also very difficult to ensure that your newly 
introduced genes are turned on and off at the right time in exactly the 
right place.

Furthermore, you would be introducing this DNA from the "supergiant" into 
germ line cells (i.e., either sperm or egg, you would tend to use the egg 
since only one of many sperm actually fertilize any one egg) of a human; 
this would be required so that the new DNA sequences could be turned on 
during the appropriate time during the development of the supergiant fetus. 
This would bring numerous ethical considerations, such as, what do you do 
with all the malformed (developmentally incorrect) fetuses that would be 
expected from your experiments (very few things work on the first try in 
science). How would you incubate your new creations so that they could 
develop? Surrogate moms for supergiants??? What if you have introduced DNA 
sequences that give unexpected charateristics to your supergiant humans; 
will you engineer a "lethal mutation" into your new race that can be 
activated under special conditions.

In general, the technical problems are many, but the more troubling issues 
are certainly the ethical questions that such a line of experimentation 
would raise.

Hope this answers your question. 



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