|MadSci Network: Immunology|
I found a couple articles that will probably answer your question. We don't have either journal at our institution, but you could probably find them at most major universities. Tough DF, Sprent J. Lifespan of lymphocytes. Immunol Res 1995;14(1):1-12. Abstract T and B lymphocytes comprise heterogeneous populations of cells at various stages of differentiation and activation. T- and B-cell subsets have different roles in the maintenance of immune homeostasis, and their functional differences are reflected by their respective lifespans. This review briefly summarizes the available data on lymphocyte lifespan, including the kinetics of T- and B-cell development in the primary lymphoid organs and the proliferative behavior of naive, effector and memory lymphocytes in the peripheral lymphoid compartment. http://www.ncbi.nl m.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids =7561338&dopt=Abstract Tough DF. Sprent J. Life span of naive and memory T cells. Stem Cells. 13(3):242-9, 1995 Abstract The life span of mature T cells is reviewed. Peripheral T lymphocytes are a heterogeneous population and comprise a mixture of naive, effector and memory cells. The recirculating pool of mature T cells is formed during young life through gradual release of naive T cells from the thymus. In adults, the pool of mature T cells is relatively self-sufficient, and input of new T cells from the thymus declines to low levels. Studies on T cell turnover indicate that most peripheral T cells can remain in a resting state for long periods (months in rodents and years in humans). Examination of the phenotype of dividing versus nondividing cells suggests that typical naive T cells are long-lived resting cells whereas the majority of effector and memory T cells have a much more rapid turnover. However, some memory T cells appear to divide very infrequently and eventually return to a resting state. The factors controlling the generation and maintenance of memory T cells are discussed. [References: 57] http://www.ncbi.nl m.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids =7613491&dopt=Abstract
Try the links in the MadSci Library for more information on Immunology.