Re: What are peroxidase proliferator-activator receptors (PPARs)?

PPARs are transcription factors activated by the binding of a ligand.  There 
are three know isoforms.  The alpha isoform seems to be involved in the 
lipid cholesterol pathway, whereas gamma seems to be involved in the effects 
on diabetes.  There is some new evidence that PPAR may play a role in colon 
cancer as well.

The following is a review of recent findings concerning the physiological or 
normal role of PPAR:  Nature 2000 May 25;405(6785):421-4                                                                                                                              
Roles of PPARs in health and disease. Kersten S, Desvergne B, Wahli W
 Institut de Biologie Animale, Universite de Lausanne, Switzerland.  The 
difficulty you are having is due to the fact that not much is known about 
the PPARs.  Happy reading!