|MadSci Network: Immunology|
Question: Why can't we cure AIDS and HIV by reducing body temperature? From: Maria Grade: 10-12 City: Aldridge, State/Prov.: West Midlands Country: England Area: Immunology Message ID Number: 975449371.Im I understand that the HIV and AIDS virus's are susceptible to temperature and can't survive for long outside body temperature. Why can't we kill the virus's by cooling the body into a state of suspended animation until it dies and then warm up the body, presumably free of the disease? ANSWER: There was a recent study that looked at in vitro HIV survivability at various temperatures. The study discovered that HIV survived 50% of the time at temperatures as low as 4 degreeís Celsius Ė Thatís about 39.2 degrees Fahrenheit. [Abdala N; Reyes R; Carney JM; Heimer R, Survival of HIV-1 in syringes: effects of temperature during storage. Subst Use Misuse 2000 Aug;35(10):1369-83.] With that in mind, itís obviously unreasonable to attempt viral eradication by virtue of freezing the patient. Not only will the patient be unsatisfied with the results, he will be quite dead as well! Another thing, the colder we are, the slower and less efficient the immune system works. Alternatively, allot of treatment strategies attempt to increase basal metabolic rate and temperature in patients. Back in 1994, Dr Gary Null demonstrated that after several treatments with a patient, whereupon blood was removed and heated to 116 degrees Fahrenheit, and replaced back in the patient, lowered p24 HIV protein titers to undetectable. [Interstitial virons will eventually replicate, therefore reactivating detectability.] There are several firms that work with physicians on this such as Biocontrol Technology, Inc. (412/279-9455) and HEAT INFO (201/865-4483). Another novel treatment that has been utilized with several viral diseases such as hepatitis C and HIV has been autohemotherapy and I.V. ozone. Iíve seen this clinically done, and for whatever reason, I have seen about the same results as Nullís treatments. However, Iím not going to make any direct correlations here Ė Moreover, I will point out that viral p24 protein titers do eventually return. In summary, in lowering body temperature enough in an effort to eradicate this virus will more readily result in patient death rather than cure.
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