Subject: Is a viable T-Cell Receptor Vaccine for autoimmune disease within reach?

One of the hottest areas of autoimmune disease research is the effort to 
develope a TCR vaccine. An effective vaccine must be able to stimulate an 
immune response against autoreactive T-cells(mostly CD4+T-lymphocytes)while
leaving the rest of the immune system undisturbed. A significant problem 
is posed by the fact that there are many subtypes of TCR's among 
autoreactive T-cells;an effective vaccine must generate an immune response 
against all of these TCR proteins(and their associated T-cells).

Is there substantial progress in this effort? Is an effective vaccine 
still many years away? 

Re: Is a viable T-Cell Receptor Vaccine for autoimmune disease within reach?