One of the hottest areas of autoimmune disease research is the effort to develope a TCR vaccine. An effective vaccine must be able to stimulate an immune response against autoreactive T-cells(mostly CD4+T-lymphocytes)while leaving the rest of the immune system undisturbed. A significant problem is posed by the fact that there are many subtypes of TCR's among autoreactive T-cells;an effective vaccine must generate an immune response against all of these TCR proteins(and their associated T-cells). Is there substantial progress in this effort? Is an effective vaccine still many years away?
Re: Is a viable T-Cell Receptor Vaccine for autoimmune disease within reach?
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