MadSci Network: Zoology

Re: What is the normal blood sugar level of a rat/white mouse?

Date: Wed Feb 14 18:25:17 2001
Posted By: Ingrid Dodge, Grad student, Immunology
Area of science: Zoology
ID: 981971693.Zo

Dear Lisa:

What an interesting project! What plants are you testing? I used to work in a lab where we performed islet transplants (cells of the pancreas that produce insulin) to try and find out if transplantation could be a cure for type I diabetes. Most people use a benchmark of between 200-300 mg/dl blood glucose on two occasions as diabetic (we used 240mg/dl). A normal mouse will have a blood glucose of around 100 mg/dl (between 60-130) after a 4 hour fast (this is close to humans, where 80-120 is considered normal). Directly after a meal, before the insulin has had time to kick in and pull the glucose out of the blood stream, it may spike up higher, but it should return down to around 100mg/dl again. You can also measure urinary glucose, in which case 500mg/dl is considered diabetic.

I hope this helps and good luck! Ingrid Mad Scientist

References: 1) Serreze DV, Ottendorfer EW, Ellis TM, Gauntt CJ, Atkinson MA. Acceleration of type I diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets. Diabetes. 49(5): 708-11, 2000 May. 2) Keren P, George J, Shaish A, Levkovitz H, Janakovic Z, Afek A, Goldberg I, Kopolovic J, Keren G, Harats D. Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: extablishment of a combined model and association with heat shock protein 65 immunity. Diabetes. 49(6): 1064-9, 2000 June. 3) Ablamunits V, Quintana F, Reshef T, Elias D, Cohen IR. Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway. Journal of Autoimmunity. 13(4): 383-92, 1999 December. 4) Wong FS, Janeway CA Jr. Insulin-dependent diabetes mellitus and it animal models (review). Current Opinion in Immunology. 11(6): 643-7, 1999 December.

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