MadSci Network: Cell Biology |
The answer to your question is yes. There are pluripotent stem cells found in human umbilical cord blood. These cells are hematopoietic stem cells, which means they give rise to cells that comprise the immune system. The UCB hemaotpoietic stem cell can give rise to myeloid cells, T cells, NK cells, and B cells. To my knowledge, these cells have not been induced to form muscle cells. Stem cells isolated from the brains of adult mice (Clark et al. Science 288, Number 5471, Issue of 2 Jun 2000, pp. 1660-1663.) can give rise to muscle and liver cells under special culture conditions. And, in countries where human embryonic research is allowed, studies of Parkinsons disease have shown that embryonic tissue injected into the brains of patients can "find" the affected area of the brain and alleviate symptoms. The term pluripotent refers to the capacity of a single cell to give rise to several different lineages of cells and renew itself. Pluripotency can occur at several levels. The penultimate pluripotent cell is the fertilized egg, which can give rise to every cell in the body. Also present in the bone marrow (and UCB) are pluripotent hematopoietic stem cells which can give rise to several lineages of hematopoietic cells, but not other types of cells. Cells which can give rise to three or two lineages might be more aptly named multipotent cells. The cell type which develops from the stem cell, depends on the environment in which these cells find themselves. A cell which migrates to the bone marrow might develop into a B cell, whereas a cell which migrates to the thymus might develop into a T cell. Environmental cues are crucial in the differentiation of these stem cells. However, since the hematopoietic stem cell gives rise to hematopoietic cells, it will not give rise to a muscle cell, regardless of the environment in which it finds itself. You can find out more about stem cells by looking up these websites. 1.Stem Cells: A Primer, National Institutes of Health, May 2000 - This primer presents background information on stem cells. http://www.nih.gov/ news/stemcell/primer.htm 2.Scientific American: Science and the Citizen: Stem Cells Come of Age: July 1999. http://www.sciam.com/1999/0799issue/0799scicit4.html 3.Stem Cells - Web site for Stem Cells. http://stemcells.alphamedpress.org/
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