MadSci Network: Immunology |
There are several ways in which an immune response is turned off. First, if T cells are activated repeatedly, when virus is present, the T cells begin to express a suicide protein on the cell surface. The suicide protein interacts with its ligand on another cell and that causes the cell to die. Second, when the virus has been cleared, the T cells are no longer activated to produce lymphokines. The activated T cells "starve" to death without the lymphokines. Third, some researchers have found T cells which actively suppress the activated T cells. Exactly how these different pathways interact and mediate the suppression of an immune response is unknown, but is actively being researched. Thank you for your question.
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