MadSci Network: Immunology
Query:

Re: Are multipotent stem cells in red bone marrow considered lymphoid tissue?

Date: Tue Apr 17 17:30:00 2001
Posted By: Brian Edelson, MD/PhD Student
Area of science: Immunology
ID: 985837597.Im
Message:

Lymphoid tissues in general can be classified as either generative or 
peripheral lymphoid tissues.  In generative tissues, lymphocytes develop and 
mature.  In adult mammals, these tissues are the bone marrow, and the 
thymus.  In peripheral lymphoid tissues, mature lymphocytes respond to 
foreign substances, called antigens.  These tissues are the lymph nodes, 
spleen, mucosa-associated lymphoid tissue, and skin-associated lymphoid 
tissue.

As far as multipotent stem cells go, these cells exist in the bone marrow.  
They are self renewing (in other words, they can divide and give rise to 
more stem cells).  They also have the capacity of differentiating into cells 
of either the lymphoid or myeloid lineages.  Under certain conditions, the 
stem cell differentiates into a lymphoid progenitor, which then further 
differentiates into either a B or T lymphocyte.  Under other conditions, the 
stem cell differentiates into a myeloid progenitor, which then further 
differentiates into either red blood cells, platelets, basophils, 
eosinophils, neutrophils, or monocytes.  To note is that the multipotent 
stem cell itself is classified as neither being of the lymphoid nor myeloid 
lineage.  It is just a special cell type, found in the marrow, which can 
differentiate into either the lymphoid or myeloid lineages.

Hope this helps.



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