MadSci Network: Immunology |
Lymphoid tissues in general can be classified as either generative or peripheral lymphoid tissues. In generative tissues, lymphocytes develop and mature. In adult mammals, these tissues are the bone marrow, and the thymus. In peripheral lymphoid tissues, mature lymphocytes respond to foreign substances, called antigens. These tissues are the lymph nodes, spleen, mucosa-associated lymphoid tissue, and skin-associated lymphoid tissue. As far as multipotent stem cells go, these cells exist in the bone marrow. They are self renewing (in other words, they can divide and give rise to more stem cells). They also have the capacity of differentiating into cells of either the lymphoid or myeloid lineages. Under certain conditions, the stem cell differentiates into a lymphoid progenitor, which then further differentiates into either a B or T lymphocyte. Under other conditions, the stem cell differentiates into a myeloid progenitor, which then further differentiates into either red blood cells, platelets, basophils, eosinophils, neutrophils, or monocytes. To note is that the multipotent stem cell itself is classified as neither being of the lymphoid nor myeloid lineage. It is just a special cell type, found in the marrow, which can differentiate into either the lymphoid or myeloid lineages. Hope this helps.
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