MadSci Network: Medicine
Query:

Re: where is Testosterone produced in Females and what functions does it have?

Date: Mon Aug 6 22:50:01 2001
Posted By: William M. Rich, MD faculty,Univ. Med. Ctr
Area of science: Medicine
ID: 996021015.Me
Message:

Elena,

Testosterone is a definite molecule with a defined chemical structure, unlike estrogen, which is a term for several molecules that have estrogenic properties. There are other molecules that also have androgenic properties.

Androgens, estrogens and progesterone are all steroids. Steroids are produced by the gonads and adrenal glands. There are several steps in producing these molecules. Some of the intermediates also have androgenic and estrogenic properties.

FSH causes the ovary to start maturing an egg. The granulosa-thecal cells associated with the egg produce estrogens, mainly estradiol. The androgens: dehydroepiandrosterone, androstenedione and testosterone are precursors of estradiol. Estradiol has the same chemical structure as testosterone with some minor electronic reconfigurations.

The adrenal also produces androgenic substances as well as some testosterone. Peripheral fat in obese women also converts some of the adrenal precursors to the estrogen estrone. This is a source of excess estrogen in obese postmenopausal women.


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