MadSci Network: Development |
Stem cells…. what a huge and hot topic today! First of all, what are stem cells? Stem cells are a 'pluripotent' type of cell, i.e. a cell that has the potential to grow into many different types of tissue e.g. bone, brain, muscle, skin etc. They are found in their greatest quantities in embryos - embryonic cells have the ability to grow into all the different cell types that make up a human being. At the moment the best source of stem cells is from human embryos…which is where the ethics of this topic kicks off (but I won't enter that discussion now!). Umbilical cord blood is another rich source of pluripotent stem cells. Blood from umbilical cords is easy to collect after a baby has been delivered and there is no risk to the mother or baby. Up to 120ml can be collected from one umbilical cord. Blood from umbilical cords, with it's supply of stem cells is presently being used to treat diseases such as leukemia, sickle cell anemia and Hodgkin's diseases, illnesses that are typically remedied by adult bone marrow transplants. In these cases bone marrow is usually donated by family members or someone whose tissue has been typed to match that of the patient. There is less risk to the patient when they are given umbilical blood because the young stem cells are less immunologically active and may pose less risk of developing graft-versus-host-disease (GVHD) - a debilitating and sometimes fatal complication that occurs when donor blood cells attack the host's (patient's) body tissues. Once transplanted the healthy stem cells replace the damaged or diseased cells. Current research is aimed at understanding exactly how to use stem cells to cure a myriad of diseases such as Alzheimer's disease, diabetes, heart disease, spinal cord injuries and burns. Scientists need to understand what drives stem cells to morph into particular tissue types and how they could be encouraged to differentiate into the particular cell type required. Other research uses stem cells to understand more the fundamental aspects of development that cannot be studied directly during human pregnancy. Understanding these events may have clinical significance for preventing and treating birth defects, infertility and pregnancy loss.
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