MadSci Network: Genetics |
Polydactyly (an abnormal numbers of digits) can be associated with over 150 different conditions, and , occasionally, can be inherited in some familial conditions as a dominantly inherited trait. However, this is usually caused by a mutation in a gene involved in proper limb development. Frequently, polydactyly is part of a more complicated picture (or syndrome) in which other abnormalities are present. Sometimes these are fatal or life-threatening, so the mutation is not passed on to future generations. In families with isolated inherited polydactyly (no other abnormalities) 50% of an affected indvidual's children will also have this trait, so in this family the number of children with 5 digits would be equal to those with more that 5. However, these mutations and these families are rare, so the vast majority of us have 5 digits.
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