|MadSci Network: Genetics|
Penny, Other diseases they have seen a possible pattern of genetic anticipation are Crohn's Disease, Bipolar Disorder, and rheumatoid arthritis. Researchers are trying to find a link with some of the mentioned diseases to specific genes assuming that genetic anticipation occurs. In some of these diseases, the exact cause in not known and there hare hopes that the possible characteristics of genetic anticipation may help located genes that cause the disease. However, the causation for trinucleotide repeat expansion is not yet known. One researcher has written a review article (Semin Neurol 1999;19 (3):289-99 Expanded repeat sequences and disease.) where they look at "the occurrence and properties of repeats in the genome" as well as "the different groups of disorders and possible pathogenic mechanisms." Most researchers are using the phenotypic data to determine if there is a genetic link otherwise not seen previously. Sincerely, Mike
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