MadSci Network: Genetics
Query:

Re: CAN SOMEONE WITH o BLOOD BE IN THE BOMBAY GROUP?

Date: Fri Jan 31 12:31:39 2003
Posted By: Michael Watson, Biomedical Engineer currently Teaching Math/Biology
Area of science: Genetics
ID: 1043340351.Ge
Message:

Generally, based on the ABO blood chart a parent with AB and parent with O 
will have a child with blood type A or B.  For this to happen the H-
antigen must be present.  However, if each parent has one recessive gene 
for the H-antigen the blood type the child may receive both recessive H-
genes and thus phenotypically express their blood type as O instead of A 
or B.  

This is known as the bombay phenotype, named because of a higher occurance 
in Bombay.  The higher occurance has been seen with the marraige of first 
cousins.  Since the family may have one recessive H-antigen gene, marrying 
in the family increases the possibility of the child to have both genes be 
recessive H- genes.  After many generations, the population has a higher 
occurance of this phenotype.

An excellent website with more information about this is 
(http://anthro.palomar.edu/blood/ABO_system.html) hope this answers your 
questions.

Michael Watson


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