Re: What processes lead to lysis of erythrocytes after Na+ influx is inhibited?

I found two references reporting that phenamil blocks inwardly rectifying 
potassium channels, at least in myocytes (Guia et al. 1995, Guia et al 
1996).  I don't know if there are potassium channels in erythrocytes that 
are sensitive to phenamil, but if there were, then phenamil could block 
potassium flux in erythrocytes.  If this flux is an outward flux (i.e., 
it is responsible for potassium efflux), then potassium would accumulate 
inside the red cell, leading to swelling and lysis.

I hope that this helps to block your losing your mind.


Guia A, Leblanc N, Bose R.  (1995)  Effects of phenamil on potassium and 
calcium channels of guinea pig ventricular myocytes  J. Pharmacol Exp 
Ther 274: 649-56

Guia A, Chau T, Bose D, Bose R. (1996)  Mechanism of cardiac inotropy by 
phenamil, and epithelial sodium channel blocker.  J Pharmacol Exp Ther 
277: 163-73