MadSci Network: Genetics |
From http://www.derm .med.ed.ac.uk/teaching/redhairgen.htm ------------------------------- by J.L. Rees Red Hair Genetics ... Several years ago, I and colleagues, discovered that the melanocortin 1 receptor, a protein encoded by a gene previously discovered in mice, was responsible for the production of red hair in humans. Everybody has two copies of this gene but there are slight changes in the gene that are very common in European populations. If you have one of about four or five common changes in this gene and, one of these changes are found on both of your chromosomes, then you are likely to have red hair. A little bit of basic genetics; you have two copies of every gene, you inherit one from your mother and one from your father. If both of these genes are different, with respect to the changes that might lead to red hair, then you will have red hair. If however you only have one change, you have an increased chance of having red hair but it is not certain that you will have red hair. Such a type of inheritance is described to by geneticists as an autosomal mode of inheritance. This means, in practice, that both your parents may not have red hair, but both could be carriers for the gene for red hair. If this was the case, perhaps one in four of their children might have red hair. If one of the parents has bright red hair, and therefore carries two of the changes (one on each of their chromosomes), and the other parent is a carrier, then perhaps 50% of their children might have red hair. It is this aspect of genetics, and the mode of inheritance, that explains why hair colour might skip generations. There are different sorts of red hair. Some people seem to have what we call “strawberry blonde”, some bright red and some auburn. As far as we know, the genetics underlying these differences are fairly similar, in that changes in the gene referred to above, seem to be important for all sorts of red hair. However, if you have bright red hair it seems you are much more likely to carry two different copies of the gene than if you are a strawberry blonde. We are, however, not completely certain about some of the details in this particular aspect of the work. ... From http://www.howstuffwork s.com/question593.htm -------------------------------- U.S. Blood-type Distribution O+ 38 percent of population A+ 34 percent of population B+ 9 percent of population O- 7 percent of population A- 6 percent of population AB+ 3 percent of population B- 2 percent of population AB- 1 percent of population ----------------------------------------------------------- Notice in the www page about red hair, that the author is not talking about a "red hair gene". He (or she) is talking about differences in one gene. This is most often the case in genetics, that there is not a "red hair gene" and a "blonde hair gene" and a "brown hair gene" but instead there are a few genes that control something like hair color, and each of those genes can have various different forms (usually just single point mutations when we are talking about humans) which are called "alleles". There are two basic reasons why an allele can be rare. One is that it is a new one that has not had time to spread through a population yet. The other is that the allele is detrimental (or less beneficial than the alternative alleles) so it is being selected out of the population. Most alleles for most genes are relatively neutral or can be beneficial in some circumstances and detrimental in others. The result is that we see an increase in diversity over time, as more alleles accumulate in a population. That diversity then tends to create a stronger species as a whole, because the diversity provides many more chances that one of the diverse types will be strong and fit for surviving a change. For a simple example, people who can gain weight on very little food are best fit for surviving famine but may be less fit for survival when too much food is available (they have risks for heart disease and diabetes). People who stay slim no matter how much food is available are less fit for surviving famine but slightly more fit for surviving in abundance. A pouplation of diverse people, some slim and some not, has the best chance overall to survive in cycles of abundance and famine. In many or most cases, the traits we observe are not linked to the genes (or alleles) and their benefit or detriment to survival in a simple way. For example the alleles that lead to red hair may have some benefit to people who live in northern climates and wear a lot of clothes. Sunlight is needed to produce vitamin D in humans, and the alleles for red hair are either directly involved or linked to alleles for skin color. Dark skin needs more sunlight to produce vitamin D, light skin needs less sunlight because there is less pigment blocking the sunlight. So light skin has a slight selective advantage in the far north (and south, but there is less human-inhabited land mass down there). Dark skin has a slight selective advantage near the equator and at high altitudes (because too much sun causes sunburn, skin cancer and other problems). The human race as a whole is best suited for survival if we have individuals that differ in many traits.
Try the links in the MadSci Library for more information on Genetics.