MadSci Network: Cell Biology
Query:

Re: how much time does a cell spend in each phase, such as interphase, ect.

Date: Mon Jun 30 15:09:47 2003
Posted By: Elena Rodriguez, Grad student, Molecular and Cell Biology, University of California, Berkeley
Area of science: Cell Biology
ID: 1056050644.Cb
Message:

Well, this question is one that can definately be answered- so I don't
think it is exactly a "trick" question. The problem is that timing or
kinetics of the cell cycle varies greatly from cell type to cell type.  An
early embryonic cell can complete the cell cycle as quickly as 14 minutes
(during cleavage, embryonic cells do not have a G1 phase between mitosis and
DNA synthesis) and tumor cells can complete the cycle in several hours. 
Some cells do not have a G1 phase and other do not have a G2 phase, however
there are 3 fetures of the cell cycle that are universal: they must grow in
size, they must replicate the DNA and they must undergo mitosis to divide
the duplicated genome.
Cells which are "quiescent" and have temporarily exited the cell cycle,
typically need at least 10-12 hours before begining DNA synthesis,
regardless of the stimulus used to trigger S phase entry. For Eukaryotic
cells which all have the same amount of DNA to be replicated, average time
to complete S phase is 8-10 hours.
If you are interested in reading more about the kintetics of the cell cycle-
you can check out the article by Howard and Pelc (1951) that established
the 4 phases of the cycle. (Exp Cell Res 2:178-187)




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