MadSci Network: Cell Biology |
Well, this question is one that can definately be answered- so I don't think it is exactly a "trick" question. The problem is that timing or kinetics of the cell cycle varies greatly from cell type to cell type. An early embryonic cell can complete the cell cycle as quickly as 14 minutes (during cleavage, embryonic cells do not have a G1 phase between mitosis and DNA synthesis) and tumor cells can complete the cycle in several hours. Some cells do not have a G1 phase and other do not have a G2 phase, however there are 3 fetures of the cell cycle that are universal: they must grow in size, they must replicate the DNA and they must undergo mitosis to divide the duplicated genome. Cells which are "quiescent" and have temporarily exited the cell cycle, typically need at least 10-12 hours before begining DNA synthesis, regardless of the stimulus used to trigger S phase entry. For Eukaryotic cells which all have the same amount of DNA to be replicated, average time to complete S phase is 8-10 hours. If you are interested in reading more about the kintetics of the cell cycle- you can check out the article by Howard and Pelc (1951) that established the 4 phases of the cycle. (Exp Cell Res 2:178-187)
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