|MadSci Network: Immunology|
as we all know is that the mainstay of hybridoma technology is the fusion between a myeloma cell and normal cell secreting or producing the required compound between the same or different species. we know that both the myeloma/ transformed cells as well as the normal cells are dioploid. thus a fused cell resulting in a fused nucleus should give rise to a tetraploid nucleus. normally animal cells cannot tolerate polyploidy , then how does the hybridoma cells survive and maintain normal ( or oncogenic) functions. please provide me with the plausuble answer ritankar majumdar
Re: non-occurance of polyploidy in hybridomas
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