|MadSci Network: Cell Biology|
The closing of gap junctions are controlled by various gating mechanisms depending on the type of gap junction and its environment (eg type of tissue). Gap junctions can respnd to a variety of physiological conditions including cAMP-dependent protein phosphorylation, rises in intracellular calcium, decreased pH, and differences in cytoplasmic potentials btween two connected cells as well as changes in membrane potential. Hille, B. Ion Channels of Excitable membranes, 3rd edition, Sinaer Associates, Inc., 2001, pages 300-304.
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