MadSci Network: Cell Biology |
That's an excellent question. You are right that animal cells are more complex than bacterial cells. Animal cells have more DNA. This DNA is present in multiple linear pieces in animal cells, whereas bacterial cells have a single circular piece of DNA. In addition, animal cells have structures called organelles, responsible for unique tasks required for cell survival. The amount of DNA and the division of labor by organelles contributes to the complexity of animal cells. It is precisely the increased complexity that gave rise to the different replication processes used by animal cells and bacterial cells. While the biochemical process of replicating the DNA is very similar in animal cells and bacterial cells, the mechanical processes of segregating the DNA and intracellular components are different. For the bacterial cell, as the DNA is replicated, the original DNA and the new copy are attached to the plasma membrane. As the bacterial cell grows the two DNAs are separated because the plasma membrane between them expands. The septum (a new piece of plasma membrane) grows between the two chromosomes and eventually divides the cell in two. The simple replication and division (called binary fission) of bacterial cells would not work for animal cells. Why not? First, the DNA material in animal cells is separated from the rest of the cell by a double membrane, so the DNA cannot readily become attached to the plasma membrane. Second, in an animal cell there are many chromosomes. In a human for example, there are 46 chromosomes. There would not be sufficient plasma membrane to which to attach in an organized fashion all of the chromosomes and their copies. Third, because the animal cell has so many chromosomes, it must have a mechanism for keeping track of each chromosome and its copy to make sure each daughter cell gets one each of the chromosomes. During mitosis (animal cell division) a spindle apparatus is formed. The spindle apparatus looks like two bicycle wheels right next to each other with the spokes of the two wheels connected in the center of the cell. These spokes protrude into the center of the cell and become associated with the chromosomes. {Each bicycle wheel eventually corresponds to a daughter cell.} The association of the spokes with the chromosomes allows one copy of each chromosome to be moved to each daughter cell. Fourth, each daughter cell must not only inherit a copy of each chromosome, but also receive appropriate amounts of organelles. During the process of animal cell replication and division, the DNA and organelles are replicated then apportioned to the daughter cells. The process of animal cell division (mitosis) is quite well understood on a molecular level and well-documented using fluorescence microscopy. To get more details about mitosis, check out a basic cell biology textbook like Essential Cell Biology by Alberts and others (Garland Science). Happy reading!
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