MadSci Network: Genetics

Re: Do you know of a percentage of triple X women who are fertile and infertile

Date: Thu Feb 12 06:10:42 2004
Posted By: David Mallory, Faculty, Biological Sciences, Marshall University
Area of science: Genetics
ID: 1075499624.Ge


The following was provided by Dr. Alain Blanchetot, Marshall University. 
He writes:  

It looks that triple X women could have some kind of developmental delay 
and learning disability but fertility appears normal
Looks at this page 
Can triple-X women have children? 
Knowledge about fertility in triple-X women is scanty and dates 
exclusively from selected, single cases of triple-X women with children. 
The only investigation of non-selected triple-X girls diagnosed by 
investigation of all new-born children comprises 50 triple-X girls from 
Denmark, Canada, USA and Scotland. The oldest of these girls are 20 years 
old at the present time. Not till these triple-X girls have reached the 
age of 40 will we have sufficiently good knowledge about fertility of 
triple-X women. 

We know, however, that triple-X women are fertile and able to have 
children, and their fertility is most probably normal. We also know that 
in nearly all cases, where children of triple-X women have had chromosome 
examination made, there have been normal chromosomes and not as one might 
expect several children with either triple-X (47,XXX) or KIinefelter's 
syndrome (47,XXY). 

In previous studies it has been mentioned that triple-X women may have an 
early menopause, that is cessation of menstruations. There are, however, 
no real evidence for this. Also conditions concerning the age at menopause 
cannot be determined until the above mentioned group of unselected triple-
X women have reached the age of 40-50 years. 

In Denmark and countries with the possibility of having prenatal 
chromosome examination made, triple-X women may have such an examination 
made, but these women most probably do not have any increased risk of 
having children with chromosome aberrations.

and further he provides:

I have looked a 2 clinical genetic books
1- Molecular medical genetics by P. Hoffee
2- Principles of medical genetics from Emery and Rimoins

47, XXX syndrome: In nearly 100% of the case the extra X is derived from 
the mother.  The physical development is normal. Affected females are 
usually tall and do not present with dysmorphic features.  The onset of 
puberty is normal and most affected individuals are a normal reproductive 
competency, normal sex life and they are able to produce normal offspring 
having no chromosomal abnormalities.  These patients are at increased risk 
of developing psychiatric problems ie schizophrenia
  Hope this answer your question

I do hope that Dr. Blanchetot's answer helps!

David Mallory
Department of Biological Sciences
Marshall University

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