|MadSci Network: Genetics|
Chris: The following was provided by Dr. Alain Blanchetot, Marshall University. He writes: It looks that triple X women could have some kind of developmental delay and learning disability but fertility appears normal Looks at this page Can triple-X women have children? Knowledge about fertility in triple-X women is scanty and dates exclusively from selected, single cases of triple-X women with children. The only investigation of non-selected triple-X girls diagnosed by investigation of all new-born children comprises 50 triple-X girls from Denmark, Canada, USA and Scotland. The oldest of these girls are 20 years old at the present time. Not till these triple-X girls have reached the age of 40 will we have sufficiently good knowledge about fertility of triple-X women. We know, however, that triple-X women are fertile and able to have children, and their fertility is most probably normal. We also know that in nearly all cases, where children of triple-X women have had chromosome examination made, there have been normal chromosomes and not as one might expect several children with either triple-X (47,XXX) or KIinefelter's syndrome (47,XXY). In previous studies it has been mentioned that triple-X women may have an early menopause, that is cessation of menstruations. There are, however, no real evidence for this. Also conditions concerning the age at menopause cannot be determined until the above mentioned group of unselected triple- X women have reached the age of 40-50 years. In Denmark and countries with the possibility of having prenatal chromosome examination made, triple-X women may have such an examination made, but these women most probably do not have any increased risk of having children with chromosome aberrations. http://www.aaa.dk /TURNER/ENGELSK/TRIPLEX.HTM#cause and further he provides: I have looked a 2 clinical genetic books 1- Molecular medical genetics by P. Hoffee 2- Principles of medical genetics from Emery and Rimoins 47, XXX syndrome: In nearly 100% of the case the extra X is derived from the mother. The physical development is normal. Affected females are usually tall and do not present with dysmorphic features. The onset of puberty is normal and most affected individuals are a normal reproductive competency, normal sex life and they are able to produce normal offspring having no chromosomal abnormalities. These patients are at increased risk of developing psychiatric problems ie schizophrenia Hope this answer your question Alain I do hope that Dr. Blanchetot's answer helps! David Mallory Department of Biological Sciences Marshall University
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