MadSci Network: Cell Biology

Re: how many kinds of animal has been cloned??

Date: Mon Apr 12 14:41:58 2004
Posted By: Paul Szauter, Staff, Mouse Genome Informatics
Area of science: Cell Biology
ID: 1078237929.Cb

The organisms that have been cloned so far include sheep, mice, cattle, pigs, goats, rabbits and 
cats. Cloning has so far been unsuccessful in dogs, primates and rats.

Please see:
Mullins LJ, Wilmut I, Mullins JJ. Nuclear transfer in rodents. J Physiol. 2004 Jan 1;554(Pt 1):4-12.


1. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH Viable offspring derived from fetal and 
adult mammalian cells. Nature 1997 385:810-813 Erratum in: Nature 1997 386:200


1. Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R Full-term development of mice 
from enucleated oocytes injected with cumulus cell nuclei. Nature 1998 394:369-74

2. Rideout W M, Wakayama T, Wutz A, Eggan K, Jackson-Grusby L, Dausm J Generation of mice 
from wild-type and targeted ES cells by nuclear cloning. Nature Genetics 2000 24:109-110


1. Kato Y, Tani T, Sotomaru Y, Kurokawa K, Kato J, Doguchi H, Yasue H, Tsunoda Y Eight Calves 
Cloned from Somatic Cells of a Single Adult. Science 1998 282:2095-2098

2. Renard JP, Chastant S, Chesne P, Richard C, Marchal J, Cordonnier N, Chavatte P, Vignon X 
Lymphoid hypoplasia and somatic cloning. Lancet 1999 353:1489-91

3. Wells D, Misica PM, Tervit HR Production of Cloned Calves Following Nuclear Transfer with 
Cultured Adult Mural Granulosa Cells. Biology of Reproduction 1999 60:996-1005

4. Kubota C, Yamakuchi H, Todoroki J, Mizoshita K, Tabara N, Barber M, Yang X Six cloned calves 
produced from adult fibroblast cells after long-term culture. Proc. Natl. Acad. Sci. USA 97:990


1. Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares 
DL, Colman A, Campbell KH. Cloned pigs produced by nuclear transfer from adult somatic cells. 
Nature. 2000 407:86-90.

2. Betthauser J, Forsberg E, Augenstein M, Childs L, Eilertsen K, Enos J, Forsythe T, Golueke P, 
Jurgella G, Koppang R, Lesmeister T, Mallon K, Mell G, Misica P, Pace M, Pfister-Genskow M, 
Strelchenko N, Voelker G, Watt S, Thompson S, Bishop M. Production of cloned pigs from in vitro 
systems. Nature Biotechnology 2000 18:1055-9.

3. Onishi A, Iwamoto M, Akita T, Mikawa S, Takeda K, Awata T, Hanada H, Perry AC. Pig cloning 
by microinjection of fetal fibroblast nuclei. Science. 2000 Aug 18;289(5482):1188-90.


1. Baguisi A, Behboodi E, Melican DT, Pollock JS, Destrempes MM Production of goats by somatic 
cell nuclear transfer. Nature Biotechnology 1999 17: 456 - 461


 Paul Szauter
 Mouse Genome Informatics

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