MadSci Network: Genetics |
This is a great question. We can start by looking up the answer: http://www.nature.ca/genome/ 03/a/03a_11a_e.cfm Diploid length = "Close to two meters" That's no fun, in science we want to figure it out ourselves. Here are some links to web sites about DNA structure: http://www.blc.arizona.edu/Molecular_Graphics/DNA_Structure/ DNA_Tutorial.HTML http:// www.accessexcellence.org/AE/AEC/CC/DNA_structure.html http:// www.accessexcellence.org/AB/GG/structure.html http:// www.rothamsted.bbsrc.ac.uk/notebook/courses/guide/dnast.htm The last site has this statement: "E. coli has a single circular DNA molecule of 4,600,000 base pairs. The total length is 1.4 mm." We also learn from the other sites that DNA has "about" 10 base pairs per turn, and that the length of a turn is 3.4 nm (a nonometer is one billionth of a meter). This gives us two estimates of the length of a DNA molecule with a given number of base pairs. The E. coli estimate gives: 4,600,000 base pairs/1.4 mm = 3,285,714 bases/mm = 3.29 Gbp/m The 10 base pairs per turn estimate gives: 10 base pairs/3.4 nm = 2.94 bp/nm = 2.94 Gbp/m A "Gbp" or gigabasepair is 1 billion base pairs. For an estimate of the size of the human genome in base pairs we go to Ensembl: http://www.ensembl.org/Homo_sapiens/ Build 32 at Ensembl = 3,223,443,491 base pairs in the human genome = 3.2 Gbp Using the first estimate we get: 3.2 Gbp x 1 meter/3.29 Gbp = 0.973 meter/haploid human genome Using the second estimate we get: 3.2 Gbp x 1 meter/2.94 Gbp = 1.088 meter /haploid human genome So the correct answer is "about a meter" for the length of the haploid human genome or "about two meters" for the length of the diploid human genome that is in each of your cells. At Ensembl you can get estimates of the length of each chromosome in base pairs; working out this part is left as an exercise for you. Yours, Paul Szauter Mouse Genome Informatics
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