MadSci Network: Cell Biology |
Dear Phil, It is a very interesting question. This idea of using cancer antigens in order to elicit an increased immunological reactivity against tumors is being developed already in clinical trials with different strategies. One of the most promising is the vaccination with Dendritic cells. Dendritic cells are a special kind of cell which are capable of a strong activation of T Cells, which in turn perform a set of actions that will lead to tumor destruction. There many studies going on, a very interesting example is the below, developed in the São Paulo University, here in Brazil. Barbuto JA, Ensina LF, Neves AR, Bergami-Santos P, Leite KR, Marques R, Costa F, Martins SC, Camara-Lopes LH, Buzaid AC. Dendritic cell-tumor cell hybrid vaccination for metastatic cancer. Cancer Immunol Immunother. 2004 Dec;53(12):1111-8. That's a very interesting and complex issue, I hope this can lead you to go deeper in this subject. Don't hesitate in asking more. Best regards, VItor
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