Can mutations in the non-coding region of a gene result in disease?

Subject: Can mutations in the non-coding region of a gene result in disease?

Date: Sun Aug 7 05:56:11 2005
Posted by Sushmita
Grade level: teacher/prof School: Postgraduate Institute of Medicl Education and Research, Chandigarh, India
City: Chandigarh State/Province: Chandigarh Country: India
Area of science: Molecular Biology
ID: 1123412171.Mb

Message:


I am an ophthlamologist, specializing in Glaucoma. I am interested in the 
molecular biology of Primary Congenital Glaucoma. All the literature I have 
scanned only talks of mutations in the coding region of the disease-causing 
gene CYP1B1. Why hasnt the non-coding region been analyzed? Is disease not 
manifested by a mutation in the non-coding region?

Re: Can mutations in the non-coding region of a gene result in disease?

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