MadSci Network: Molecular Biology
Query:

Re: Is the gene regulation in prokaryotes more or less complex than eurkaryotes

Date: Sun Oct 23 23:23:45 2005
Posted By: Devendra Dusane, Post-doc/Fellow, Microbiology, SRISTI
Area of science: Molecular Biology
ID: 1126814513.Mb
Message:

Is Eukaryotic gene regulation complex than prokaryote? 

Yes, Gene expression is the ability of a gene to produce a biologically
active protein, and its control mechanism must be based depending on the
complexity of the genes. 

A major difference is observed in prokaryotes and
eukaryotes based on the nuclear membrane, there is absence of a nuclear
membrane in prokaryotes. In prokaryotes, control of transcriptional
initiation is the major point of regulation, while in eukaryotes the
regulation of gene expression is controlled at many different points. Hence
the gene regulation in eukaryotes is more complex than in prokaryotes. 
The genes present in prokaryotes don’t need to be transcribed all the time.
Also the genes that affect the same biochemical pathway in prokaryotes eg.
Bacteria will be expressed under the same conditions. Therefore, it is
economical to have all of these genes grouped together under the control of
the same regulatory system. Such a grouping of similarly-regulated genes in
bacteria is called an operon. The example of operon is lactose operon in
prokaryotes. Like prokaryotes, eukaryotic organisms do not want to express
all of their genes all of the time. Since it is complex multicellular,
eukaryotic gene regulation in these organisms needs to be very complex.
Eukaryotes need to regulate their genes for different reasons than
prokaryotes. 

There are many examples of how eukaryotic cells are more complex than
prokaryotic cells. One example of this is the presence of a nucleus in
eukaryotic cells, which separates transcription from translation in a way
not seen in prokaryotes. 

References:  
http://web.indstate.edu/thcme/mwking/gene-regulation.html


http://www.emunix.emich.edu/~rwinning/genetics/proreg.htm


http://www.emunix.emich.edu/~rwinning/genetics/eureg.htm




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