MadSci Network: Molecular Biology |
Is Eukaryotic gene regulation complex than prokaryote? Yes, Gene expression is the ability of a gene to produce a biologically active protein, and its control mechanism must be based depending on the complexity of the genes. A major difference is observed in prokaryotes and eukaryotes based on the nuclear membrane, there is absence of a nuclear membrane in prokaryotes. In prokaryotes, control of transcriptional initiation is the major point of regulation, while in eukaryotes the regulation of gene expression is controlled at many different points. Hence the gene regulation in eukaryotes is more complex than in prokaryotes. The genes present in prokaryotes don’t need to be transcribed all the time. Also the genes that affect the same biochemical pathway in prokaryotes eg. Bacteria will be expressed under the same conditions. Therefore, it is economical to have all of these genes grouped together under the control of the same regulatory system. Such a grouping of similarly-regulated genes in bacteria is called an operon. The example of operon is lactose operon in prokaryotes. Like prokaryotes, eukaryotic organisms do not want to express all of their genes all of the time. Since it is complex multicellular, eukaryotic gene regulation in these organisms needs to be very complex. Eukaryotes need to regulate their genes for different reasons than prokaryotes. There are many examples of how eukaryotic cells are more complex than prokaryotic cells. One example of this is the presence of a nucleus in eukaryotic cells, which separates transcription from translation in a way not seen in prokaryotes. References: http://web.indstate.edu/thcme/mwking/gene-regulation.html http://www.emunix.emich.edu/~rwinning/genetics/proreg.htm http://www.emunix.emich.edu/~rwinning/genetics/eureg.htm
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