Re: what substance is relesed during excessive mitosis

Dear Ashish,
A basic mechanism of chemotherapy drugs is to inhibit some aspect 
mitosis. For example, cyclophosphamide is a akylating agent, it transfers 
alkyl radicals to DNA molecules which makes them useless. Methotrexate 
inhibits the Folic Acid synthesis, folic acid is fundamental for DNA 
synthesis. Therefore, the chemotherapy drugs inhibit mitosis in general, 
and all the cells in the body are affected by it. That's why chemotherapy 
has so many side effects, specially in tissues which need to replicate a 
lot, like the mouth and stomach mucosas, like the skin, like the blood 
producing(hematopoeitic) tissue in bone marrows. The great advantage is 
that you can inhibit tumor replication, but you inhibit the normal cells 
to do the needed physiological replication and tissue turnover. So, 
people receiving chemotherapy exhibit mouth bleeding, stomach bleeding, 
the skin gets thin, the hair falls, the blood elements gets scarce, the 
immune system fails. And this leads to major medical complication in this 
type of therapy. We wish we could find out tumor selective drugs like you 
asked, then, patients suffering form cancer and autoimmune diseases would 
not to go through  all the side effects related to these cytotoxic drugs.
Please do not hesitate in asking any question. All the best,
Vitor