MadSci Network: Biochemistry
Query:

Re: what are the affects of hydroflouric acid burns on DNA?

Date: Wed Aug 2 14:01:00 2006
Posted By: William Gunn, Grad student, The Center for Gene Therapy, Tulane University
Area of science: Biochemistry
ID: 1154478578.Bc
Message:

You asked about the effects of HF burns on DNA. Since you mention burns, I think you want to know if occupational exposure to HF is potentially mutagenic. It's not. In fact, hydrolysing DNA in HF does not deaminate 5-methylcytosine. The primary effect of exposure to HF is severe deep-tissue chemical burns. There are a few reports of elevated levels of reactive oxygen species in the cells of rats given fluoridated water, so it's possible that fluorine ions could contribute indirectly to DNA damage, but HF itself isn't directly mutagenic. Please note that it is spelled hydrofluoric. You can remember this if you remember that hydrofluoric acid doesn't come from flour, but from fluorine.


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