|MadSci Network: Cell Biology|
Although some element are highly conserved in all animals, (DNA polymerase, for example) the overall genetic similarity between a human and another animal (except primmates) is low. As we go further out on the branches of the evolutionary tree, there are fewer conserved sequences. Even though the nucleus controls the cell and codes for it's proteins, it relies on proteins for control and replication. So to answer your question: It depends on which animal you want to put the human nucleus into, but most likely the cell will not be viable because the nucleus could not communicate with the existing proteins of the host cell. If, however, the host is similar enough to the human to communicate (and induce cell division) the cell would produce it's own proteins and after several replications would very much resemble a human cell in both make-up and behavior. As a side note; I'm not sure (since you chose a skin cell) if you were interested in human cloning. The idea is the same, except the nucleus is put into a de-nucleated unfertilized egg of a human. I hope this answers your question, but if not please feel free to elaborate or ask another question. The following link describes evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. you can review the highlights (after the abstract. http://www.genome. org/cgi/content/full/15/8/1034
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