MadSci Network: Cell Biology |
Wissy, This is sort of a two-fold question. I’ll address the first part first. The short answer is that the various enzymes, cofactors and other cellular machinery specific to certain processes are generally only located where they are needed. Using your example of the nucleus and mitochondria, then, one can say that the proteins and membranes required to concentrate protons on one side of the membrane and allow them to fall down slowly enough for the cell to make ATP from them is only found in the mitochondria. Conversely, the proteins and chemicals necessary to create RNA and DNA from DNA templates are found only in the nucleus. These processes only occur in one organelle, and so the cell does not wish to waste energy by equipping each organelle with the machinery to carry out every process the cell can perform – that would be very wasteful. For example, if you owned two factories – one that produced shoes and one that produced radios – would you want them both to have to be able to make each others’ product? No, you would want the radio factory to be very, very efficient at making radios, and the shoe factory to be very, very efficient at making shoes. The reason that eukaryotic cells (those with membrane-bound organelles) create so many compartments to house their cellular functions is actually quite simple, when you think about it. Some cellular processes would simply interfere with other processes and decrease the efficiency of the cell. For instance, the very low pH required for the lysosomes and mitochondria to perform their recycling and ATP producing functions is far too acidic for proteins to be made. The cell, then, separates these low pH environments from the ribosome so that proteins can be made efficiently WHILE the mitochondria and lysosome and carrying out their functions. There are some cells that do not separate functionality like this. Prokaryotes (bacteria) have no internal membrane compartmentalization. All of their cellular processes are performed in a common cytosol. This is one of the major reasons that bacteria are limited in their complexity. Without being able to carry out many specialized cellular processes simultaneously, their cells are only capable of carrying out processes that are compatible with one another. That is why bacteria cannot carry out the same low-pH energy production methods we do (in general, anyway). Thanks for your question! Billy. Wikipedia has two particularly good articles that address your question. Organelles: http://en.wikipedia.org/wiki/Organelle and Eukaryotes: http://en.wikipedia.org/wiki/Eukaryotes
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