MadSci Network: Medicine
Query:

Subject: Do diuretics shorten the half life of drugs that are extreted in urine?

Date: Tue Nov 7 04:31:24 2006
Posted by Noah
Grade level: grad (science) School: none
City: Arcata State/Province: CA Country: USA
Area of science: Medicine
ID: 1162899084.Me
Message:

I've spent a good deal of time tonight trying to find the answer to this but
have had no luck. I even scanned through a intro to pharmacology book, no help.
If only I could just ask someone in the field...

I was wondering whether pharmaceuticals that are excreted by the kidney
(excreted in urine) are excreted faster when diuretics are taken. For instance,
if a drug is  not broken down in the liver etc and has a half life of 6 hours
and is known to be excreted un-modified in urine, *will the half life be
shortened when and if diuretics are taken?* This question was more complicated
than I anticipated and no source seems to treat this question directly.

Thanks for any help.


Re: Do diuretics shorten the half life of drugs that are extreted in urine?

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