MadSci Network: Cell Biology |
The cells necessarily do not divide faster at a younger age but rather the ability to divide reduces with age and hence the growth rate slows down. Cells isolated from a sample tissue termed “primary cells” can divide in culture for roughly 30 divisions after which the cells stop growing. This limit has been called the “Hayflick Limit” after the person who first described the phenomenon. However, mutations or changes in proteins that control cell cycle checkpoints during cell division leads to transformed or immortalized cells. Such cells can grow indefinitely in culture, a feature shared by cancer cells. So if your question is can we makes cells grow forever, the answer is yes but then the cells would be cancerous. A related question would be “Can the cells remain young retaining their ability to divide normally without aging?” One of the key reasons cells senesce/age is due to shortening of the ends of chromosomes called telomeres. Several human diseases that show signs of premature aging such as Fanconi anemia, Bloom’s syndrome, Werner’s syndrome etc., are associated with short telomere length. Enzymes called telomerase of which hTERT or Telomerase Reverse transcriptase is important maintain the telomere lengths. Based on experiments carried out in lower organisms, it has been thought for a while that this gene alone can prevent organisms from aging. Mammalian cells that express high levels of TERT such as stem cells and certain kind of cancer cells can grow in culture for long periods of time. It is however unclear how much of this alone is responsible for human aging.
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