Date: Thu Mar 8 05:25:52 2007
Posted By: Neil Saunders, Computational biologist
Area of science: Science History
ID: 1173217389.Sh
Message:
Hi Mathew,
Here are some answers to your questions.
-
Penicillium doesn't have a chemical structure. I think that you are
confusing
Penicillium, the mold, with
penicillin, the antibiotic extracted from the mold. Penicillium refers to a group
of fungi (a
genus). One species of this genus,
Penicillium chrysogenum, produces what we call penicillin.
In fact there are several "penicillins", both natural and synthetic, with a
variety of structures as you will see at the Wikipedia penicillin page.
-
It's difficult to say who first identified Penicillium. People have
known for thousands of years that some types of mold can be used to treat
infections, even if they didn't know the name of the mold or how it worked.
It may have been the famous scientist
Joseph Lister who first identified the mold as Penicillium, in around 1871. Another
famous scientist,
Louis Pasteur, may have been the first to identify the species of Penicillium that
secretes penicillin, in about 1874. History records that
Alexander Fleming was the first person to extract penicillin from Penicillium
chrysogenum and identify it as the antibiotic agent, in 1928-29.
There's much more information on penicillin history at the
Discovery of Penicillin page.
-
Penicillium has affected the world in a huge way. Imagine if you
lived only 100 years ago, before antibiotics. You could have become
seriously ill or even died due to a simple infection - maybe a sore throat
or a dirty cut on your finger. Many people who would otherwise have died
have been saved by the discovery of penicillin and many other antibiotics.
It's not all good news though - we have used antibiotics on such a huge
scale that some strains of bacteria are
becoming resistant to them. There are even some "superbugs" that are resistant
to virtually every antibiotic that we have.
-
Penicillin was not discovered during war, but it was used extensively to
treat people for the first time during World War II. If you go to the
links in this answer you will read about two scientists called
Howard Florey and
Ernst Chain and their role in the large scale production of penicillin.
Stay curious!
Neil
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