Subject: Why does the drug, Chloroquihne induce large vacuoles within cells?

Working aon a science project regarding determining if lysosomal malfunction 
contributed to Macular degeneration I came upon a startling finding. 
Chloroquine trated Retinal pigment cells formed large enigmatic white vacuoles 
under phase contrast microscopy. Moreoverm, there were dark dense bodies 
localized on the exterioir. Why are these vacuoles forming? Is this a cells 
defense mechanism against a foreign drug?

Re: Why does the drug, Chloroquihne induce large vacuoles within cells?