|MadSci Network: Cell Biology|
I am reviewing a paper titled : "Identification of a Regulated Pathway for Nuclear Pre-mRNA Turnover" as a part of my curriculum .This was published in Cell,Vol. 102, September 2000. Basically my question was "How different media such as Glucose or Galactose affect the activities of the cell such as transcription ,splicing etc. In particular, is this effect applicable to genes of ribosomal proteins too?I read that 90% of the splicing machinery in a cell is devoted to splicing of ribosomal protein genes in an actively growing yeast cell. So then in what medium would you consider yeast to be actively growing? Also what would happen to yeast cells pregrown in Galactose medium for 3hours were transferred to Glucose medium for 20 hours with respect to transcription ,splicing etc. [See: Bousquet-Antonelli C, Presutti C, Tollervey D. Identification of a regulated pathway for nuclear pre-mRNA turnover. Cell. 2000 Sep 15;102(6):765-75. --S.M.]
Re: The paper I am reviewing is titled : 'Identification of a Regulated Pathway
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