|MadSci Network: Immunology|
There are many scholarly articles written on the subject of T cell senescence in the elderly? Some of the more recent ones propose the use of transgenes for telomerase to enable the rejuvination of exhausted T cells. Cancer cells have lots of telomerase. Maby T cell exhaustion is evolution's way of protecting against the formation of neoplasms. How come I never read about (synthetic) thymosin alpha one or other thymic hormones to help compensate for thymic involution (and create new naive T cells)? Is it because bonemarrow stem cells in the elderly are already clonally expanded and would not make good raw material (as thymocytes)? When thyroid gland function declines, patients are routinely given synthetic thyroid hormones. Is there a parallel here, or am I missing something?
Re: Why are thymic hormones never mentioned in connection with T cell senescenc
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